The effects of 5-HT1B receptor subtypes on motor behaviors mediated by cerebellar fastigial nucleus

doi:10.13459/j.cnki.cjap.2016.06.014

Abstract

Abstract: Objective: To investigate the effects of the serotonergic nervous system on motor behaviors mediated by cerebellar fastigial nucleus (FN). Methods: In this experiment, the main methods are whole-cell patch clamp recording and Rota-rod test. Results: We found that the excitatory synaptic transmission was enhanced in the cerebella FN after blocking 5-hydroxytryptamine,(5-HT)receptor. Microinjection of 5-HT into FNs remarkably promoted motor performances on Rota-rod, which could be reversed by microinjection of 5-HT receptor antagonist SB224289. Conclusion: These results suggest that the 5-HT can suppress cerebellar FN excitatory synaptic transmission via 5-HT_1B receptors, thereby modulate the activity of cerebellar nuclear neurons circuitry, and subsequently influence the cerebellum-mediated ongoing motor balance and coordination.

Key words: 5-HT, 5-HT_1B receptor, fastigial nucleus (FN), excitatory post-synaptic currents, rat, patch clamp

CLC Number:

GAO Wei, WANG Nan, QIAO Hu. The effects of 5-HT_1B receptor subtypes on motor behaviors mediated by cerebellar fastigial nucleus[J]. CJAP, 2016, 32(6): 550-554.

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The effects of 5-HT_1B receptor subtypes on motor behaviors mediated by cerebellar fastigial nucleus

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